Contributing to the pathway towards 5G experimentation with an SDN-controlled network box

Καθώς η απαίτηση σε ευρυζωνικές υπηρεσίες κινητών επικοινωνιών αυξάνεται ραγδαία, τα υπάρχοντα δίκτυα κινητών επικοινωνιών πλησιάζουν τα όριά τους κάνοντας επιτακτική την ανάγκη εξέλιξής τους η οποία θα επέλθει με την τεχνολογική άφιξη της επόμενης γενιάς κινητών επικοινωνιών, ευρέως γνωστής ως 5G. Το 5G μεταφέρει όλες εκείνες τις δυνατότητες οι οποίες είναι απαραίτητες για να καλυφθούν οι συνεχώς αυξανόμενες ανάγκες σε ευρυζωνικές υπηρεσίες, να υποστηρίξουν το Internet of Things καθώς και να ενοποιήσουν ετερογενείς υπηρεσίες σε διαφορετικές βιομηχανίες. Η παρούσα διπλωματική εργασία στοχεύει να παρουσιάσει το “Network in a box”, ένα καινοτόμο εργαλείο που αναπτύξαμε στο εργαστήριο, το οποίο βασίζεται επάνω στους θεμέλιους λίθους του 5G, το SDN και το NFV. Με το SDN να είναι η νέα προσέγγιση στα δίκτυα κινητών επικοινωνιών, ο έλεγχος διαχωρίζεται από τα δεδομένα παρέχοντας τη δυνατότητα οποιεσδήποτε αποφάσεις ελέγχου, να λαμβάνονται κεντρικά, μετατρέποντας έτσι τις κλασικές δικτυακές συσκευές σε απλά προωθητικά στοιχεία του δικτύου. Η συγκεκριμένη διάταξη μιμείται ένα πραγματικό δίκτυο, το οποίο διαθέτει δυνατότητες αυτο-οργάνωσης και αυτο-βελτίωσης, προσομοιώνοντας τη λειτουργία του 5G δικτύου. Το συγκεκριμένο εργαλείο είναι επίσης ικανό να παράσχει KPI μετρικές του 5G δικτύου κάτω από πραγματικές συνθήκες ενόσω αληθινές δικτυακές συσκευές είναι συνδεδεμένες σε αυτό. Η δομή της παρούσας διπλωματικής εργασίας αναλύεται σε πέντε κεφάλαια. Το πρώτο κεφάλαιο παρουσιάζει τις προκλήσεις που σύντομα θα κληθούν να αντιμετωπίσουν τα δίκτυα κινητών επικοινωνιών και πώς αυτές μπορούν να καλυφθούν με την τεχνολογία του 5G. Το δεύτερο κεφάλαιο εισάγει την τάση στην αγορά των κινητών επικοινωνιών που διαφένεται πίσω από την επερχόμενη άφιξη του 5G, αποκαλύπτοντας το επιχειρηματικό πλαίσιο για επιχειρήσεις, καταναλωτές και συνεργασίες όπως επίσης και κάποιες περιπτώσεις χρήσης που αντικατοπτρίζουν την διαρκή εξέλιξη στις ευρυζωνικές υπηρεσίες κινητών επικοινωνιών. Το τρίτο κεφάλαιο εμπεριέχει μια μικρή επισκόπηση των τρέχοντων έργων πάνω στο 5G, τα οποία ξεκίνησαν υπό την αιγίδα της Ευρωπαϊκής Επιτροπής με τη συνεργασία προμηθευτών τεχνολογίας επικοινωνιών, παρόχων υπηρεσιών, μικρομεσαίων επιχειρήσεων και πανεπιστημίων. Γίνεται επίσης αναφορά στις βασικές τεχνολογίες του 5G και στις δραστηριότητες προτυποποίησής του. Προχωρώντας στο τέταρτο κεφάλαιο, περιγράφουμε σε βάθος την αρχιτεκτονική του 5G δικτύου, αναλύοντας τα SDN, NFV, MANO και εξετάζουμε πώς αυτά συνεισφέρουν στη βιωσιμότητα του δικτύου. Τέλος, στο πέμπτο κεφάλαιο εισάγουμε μια καινοτόμο ιδέα που αναπτύξαμε στο εργαστήριο δικτύων του πανεπιστημίου μας, ένα πλήρως αυτόνομο δικτυακό εργαλείο, το “Network in a box”. Παρουσιάζουμε σε βάθος πώς αυτός ο server μπορεί να εγκατασταθεί και να λειτουργήσει καθώς και τις δυνατότητές του κάτω από πραγματικές συνθήκες λειτουργίας του δικτύου, ενώ λαμβάνουν χώρα υποβάθμιση ποιότητας ή μη-διαθεσιμότητα στις δικτυακές ζεύξεις, παρέχοντας επίσης μετρικές από τη λειτουργία του δικτύου σε πραγματικό χρόνο.As the demand in mobile broadband is tremendously increased and the heterogeneity of the services to be covered is growing rapidly, current mobile networks are close to their limits imposing the need of an evolution which is going to be introduced by the next generation technology, the ITU IMT-2020, well known as 5G. 5G brings all those capabilities required to cover the increased mobile broadband needs, support the Internet of Things and bind heterogeneous services in different industries. This diploma thesis aims at presenting the “Network in a box”, an innovative tool we developed which is based on the key 5G principles, SDN and NFV. With Software Defined Networking (SDN) being the new approach in mobile networks, control and data plane are decoupled providing the ability to make any control related decisions centrally and transform legacy network devices to simple forwarding elements. This testbed is a portable emulated network device which is self-managed and self-optimised and can be connected between any real network devices, emulating how the 5G network will perform. This plug & play black-box testbed is also capable of providing KPI metrics of the 5G network under real circumstances when real network devices are connected to it. The structure of this diploma thesis is decomposed in five chapters. Chapter 1 presents the challenges mobile networks will shortly face due to the growing heterogeneous demands in communications towards the year 2020 and beyond and how these can be met with the upcoming 5G technology. Chapter 2 introduces the market trend behind the new era of 5G, revealing the business context for enterprises, consumers, verticals and partnerships as well as some use cases which reflect the continuous mobile broadband evolution. Chapter 3 includes a short overview of the ongoing 5G projects, initiated under the umbrella of the European Commission, with the collaboration of communications technology vendors, telecommunications operators, service providers, small and medium-sized enterprises (SMEs) and universities. There is also a reference in 5G key enabling technologies and standardisation activities as we move towards the next generation mobile networks technology. Moving forward, chapter 4 describes in detail the technological components of 5G network architecture such as SDN, NFV, MANO and examines how these 5G key enabling technologies contribute to the overall networks’ sustainability. Finally, in chapter 5 we introduce an innovative idea developed in our university’s communications network research laboratory, an autonomous emulated portable network testbed, the “Network in a box”. We present in-depth how this portable server is deployed, operates and demonstrate the way it can be connected to real network elements emulating a real 5G end-to-end customer network. Moreover, in this last chapter we present “Network in a box” capabilities under real network circumstances when link degradations or failures take place, providing also real-time network metrics

Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies

Dietary fat, both in terms of quantity and quality, has been implicated to cancer development, either positively or negatively. The aim of this work was to evaluate whether olive oil or monounsaturated fat intake was associated with the development of cancer. A systematic search of relevant studies, published in English, between 1990 and March 1, 2011, was performed through a computer-assisted literature tool (i.e., Pubmed). In total 38 studies were initially allocated; of them 19 case-control studies were finally studied (13800 cancer patients and 23340 controls were included). Random effects meta-analysis was applied in order to evaluate the research hypothesis. It was found that compared with the lowest, the highest category of olive oil consumption was associated with lower odds of having any type of cancer (log odds ratio = -0.41, 95%CI -0.53, -0.29, Cohran's Q = 47.52, p = 0.0002, I-sq = 62%); the latter was irrespective of the country of origin (Mediterranean or non-Mediterranean). Moreover, olive oil consumption was associated with lower odds of developing breast cancer (logOR = -0,45 95%CI -0.78 to -0.12), and a cancer of the digestive system (logOR = -0,36 95%CI -0.50 to -0.21), compared with the lowest intake. The strength and consistency of the findings states a hypothesis about the protective role of olive oil intake on cancer risk. However, it is still unclear whether olive oil's monounsaturated fatty acid content or its antioxidant components are responsible for its beneficial effects

Ceramic foam substrates for automotive catalyst applications: fluid mechanic analysis

Several properties of ceramic foams render them promising substrates for various industrial processes. For automotive applications, the foam properties that need to be further studied include the substrate impact on the exhaust gas flow, in terms of pressure drop and flow uniformity. In this paper, pressure drop measurements are performed with different honeycomb and ceramic foam substrates, and pressure drop correlations are discussed. The flow uniformity upstream and downstream of the substrates is evaluated using particle image velocimetry. The results show that ceramic foam substrates induce higher pressure drop, while increasing the uniformity of the flow. In contrast to honeycomb monoliths, the flow uniformity downstream of ceramic foams does not decrease with increasing flow velocity. The higher flow uniformity of ceramic foams is not only caused by their higher pressure drop, but also by flow homogenization that occurs inside the ceramic foam structure, as a result of the momentum exchange perpendicular to the main flow directio

Angiogenic cytokines profile in smoldering multiple myeloma: No difference compared to MGUS but altered compared to symptomatic myeloma

Background: Symptomatic multiple myeloma (MM) evolves from an asymptomatic precursor state termed monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM). Angiogenesis plays a key role in the pathogenesis of MM but there are very limited data for angiogenesis in SMM. Material/Methods We measured the circulating levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF), and angiogenin in 54 patients with SMM. The results were compared with those of 27 MGUS patients, 55 MM patients, and 22 healthy controls. The expression of VEGF-A gene was also evaluated in 10 patients with SMM, 10 with symptomatic MM, and 10 with MGUS. Results: The ratio of circulating Ang-1/Ang-2 was reduced in MM patients with symptomatic disease due to a dramatic increase of Ang-2 (p<0.001), but not in patients with SMM or MGUS, in whom it did not differ compared to controls. VEGF and angiogenin were increased in all patients compared to controls. However, circulating VEGF was higher in symptomatic MM compared to SMM and MGUS, while angiogenin was reduced. There were no differences in the expression of VEGF-A among the 3 patients categories. Conclusions: SMM has a circulating angiogenic cytokine profile similar to that of MGUS, but has altered profile compared to symptomatic MM. Thus, in the progression of MGUS to SMM, circulating angiogenic cytokines seem to be the same. On the contrary, in symptomatic myeloma, the alterations of angiopoietins along with VEGF contribute to myeloma cell growth, supporting the target of these molecules for the development of novel anti-myeloma agents

Sonographic Lobe Localization of Alveolar-Interstitial Syndrome in the Critically Ill

Introduction. Fast and accurate diagnosis of alveolar-interstitial syndrome is of major importance in the critically ill. We evaluated the utility of lung ultrasound (US) in detecting and localizing alveolar-interstitial syndrome in respective pulmonary lobes as compared to computed tomography scans (CT). Methods. One hundred and seven critically ill patients participated in the study. The presence of diffuse comet-tail artifacts was considered a sign of alveolar-interstitial syndrome. We designated lobar reflections along intercostal spaces and surface lines by means of sonoanatomy in an effort to accurately localize lung pathology. Each sonographic finding was thereafter grouped into the respective lobe. Results. From 107 patients, 77 were finally included in the analysis (42 males with mean age = 61 ± 17 years, APACHE II score = 17.6 ± 6.4, and lung injury score = 1.0 ± 0.7). US exhibited high sensitivity and specificity values (ranging from over 80% for the lower lung fields up to over 90% for the upper lung fields) and considerable consistency in the diagnosis and localization of alveolar-interstitial syndrome. Conclusions. US is a reliable, bedside method for accurate detection and localization of alveolar-interstitial syndrome in the critically ill

Maximum inspiratory pressure, a surrogate parameter for the assessment of ICU-acquired weakness

<p>Abstract</p> <p>Background</p> <p>Physical examination has been advocated as a primary determinant of ICU-acquired weakness (ICU-AW). The purpose of the study is to investigate ICU-AW development by using Maximum Inspiratory Pressure (MIP) as a surrogate parameter of the standardized method to evaluate patients' peripheral muscle strength.</p> <p>Methods</p> <p>Seventy-four patients were recruited in the study and prospectively evaluated in a multidisciplinary university ICU towards the appearance of ICU-AW. APACHE II admission score was 16 ± 6 and ICU stay 26 ± 18 days. ICU-AW was diagnosed with the Medical Research Council (MRC) scale for the clinical evaluation of muscle strength. MIP was measured using the unidirectional valve method, independently of the patients' ability to cooperate.</p> <p>Results</p> <p>A significant correlation was found between MIP and MRC (r = 0.68, p < 0.001). Patients that developed ICU-AW (MRC<48) had a longer weaning period compared to non ICU-AW patients (12 ± 14 versus 2 ± 3 days, p < 0.01). A cut-off point of 36 cmH₂O for MIP was defined by ROC curve analysis for ICU-AW diagnosis (88% sensitivity,76% specificity). Patients with MIP below the cut-off point of 36 cmH₂O had a significant greater weaning period (10 ± 14 versus 3 ± 3 days, p = 0.004) also shown by Kaplan-Meier analysis (log-rank:8.2;p = 0.004).</p> <p>Conclusions</p> <p>MIP estimated using the unidirectional valve method may be a potential surrogate parameter for the assessment of muscle strength compromise, useful for the early detection of ICU-AW.</p

Echogenic Technology Improves Cannula Visibility during Ultrasound-Guided Internal Jugular Vein Catheterization via a Transverse Approach

Objective. Echogenic technology has recently enhanced the ability of cannulas to be visualized during ultrasound-guided vascular access. We studied whether the use of an EC could improve visualization if compared with a nonechogenic vascular cannula (NEC) during real-time ultrasound-guided internal jugular vein (IJV) cannulation in the intensive care unit (ICU). Material and Methods. We prospectively enrolled 80 mechanically ventilated patients who required central venous access in a randomized study that was conducted in two medical-surgical ICUs. Forty patients underwent EC and 40 patients were randomized to NEC. The procedure was ultrasound-guided IJV cannulation via a transverse approach. Results. The EC group exhibited increased visibility as compared to the NEC group (88%  ± 8% versus 20%  ± 15%, resp. P < 0.01). There was strong agreement between the procedure operators and independent observers (k = 0.9; 95% confidence intervals assessed by bootstrap analysis = 0.87–0.95; P < 0.01). Access time (5.2 s ± 2.5 versus 10.6 s ± 5.7) and mechanical complications were both decreased in the EC group compared to the NEC group (P < 0.05). Conclusion. Echogenic technology significantly improved cannula visibility and decreased access time and mechanical complications during real-time ultrasound-guided IJV cannulation via a transverse approach